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Dr Ross Piper – Deceivers, Doppelgangers and Degenerates

On Wednesday 1st March we’re delighted to welcome zoologist, entomologist and explorer Dr Ross Piper to PubSci.

piper

Animals are dazzlingly diverse, yet we know next to nothing about them, from how many species there are on Earth to how they live. Why is this? Ross will explore this question in his talk and offer some answers that may surprise you and even provide a whole new perspective on how much we still have to discover.

Join us upstairs at the Old King’s Head, near London Bridge station. Doors open at 6pm for a 7pm start and as usual the event is free, but we will have a whip-round to cover costs – we hope to see you there!

Pubsci – Archive

Grand_Study_Hall_New_York_Public_Library

Welcome to the Pubsci archive, this is where you can find all the old events and posts from pubsci’s of yore, up until Jan 2013

Pubsci is moving

Dear all,

To help make improvement to our site making events easier to track and new content more prominent we are making changes to the site.

This will involve a couple of days of disruption and tweaks to our the site

We will try to get back to normal service asap

Sorry fo any confusion

The pubsci team

Designer Drugs 101: a Review

Many people say that the UK has some very strange, outdated laws – citing anecdotal examples involving Welshmen in Chester after sun-down. I don’t think you need to go much farther than our drugs legislation to find really loony stuff:

Last night I attended a talk by Dr James Moffat of St. George’s University on the subject of Pharmacology. Dr Moffat opened by stating that he is a cardiovascular specialist and that there will definitely be some questions raised by his talk that require a neurobiologist, or a lawyer, or a politician to give us the sort of detail we are looking for.

He started off by showing us a line of powder on a mirror and asking us to identify it. Naturally the consensus was Cocaine but the photograph was of Salbutamol (commonly known as “Ventolin”) which saves more lives than Cocaine will ever take.

He explained that the brain works by pattern recognition and that it determines what it has taken by which receptors the chemical has triggered. He demonstrated this by asking us to imagine that our brains were simplified and had 1 receptor for each celebrity. Our eyes receive parts of these celebrities and our ‘celebrity receptors’ tell us who they have seen. We were shown a slide of George Clooney’s mouth, and another with Angelina Jolie’s eyes. In both cases the audience as a unit managed to identify the celebrities. Dr. Moffat then unveiled his scariest slide of all: an amalgam of Clooney and Jolie (“Georelina Cloolie”?). He explained that the brain receives the effects of chemicals in the same way: if a drug is designed to affect two receptors, we’ll recognise both at once with different parts of our brain.

Designer drugs target receptors in the brain responsible for releasing neurotransmitters, the key compounds targeted are: serotonin, which induces the happy response; dopamine, responsible for the reward response and addictive qualities; and noradrenalin, the effects of which are complex and still being discovered. The experience you get from taking the substance is based on the extent to which the substance interferes with normal brain activity in the receptors.

Substances such as caffeine, nicotine, and alcohol also interfere with the natural function of the brain in very similar ways. Why are they legal and other drugs aren’t? Also, what about ‘legal highs’ purchased in new age shops? These aren’t FDA approved drugs that get criminalised when new evidence comes to light: these have never been through any kind of official regulatory body whatsoever, nor do they need to have undergone any testing whatsoever. As Dr. Moffat puts it: “‘legal highs’ are an experiment on the general public done by scumbags”.

Let me stop for a moment and point something out here: an English establishment can be shut down for continuing to sell food where the ingredients are listed only in a foreign language because there is a good chance the consumer won’t know what they are consuming, and yet there is little to no regulations on the sale of substances for which the molecular structure is completely unknown. Something is very clearly wrong here.

The criminalisation of substances can, in some cases (such as in Phenethylamines), lead to the outlawing wholesale of any substance which contains the same molecular structure as the banned substance (except where it already has proven medicinal benefits, such as Bupropion). We are at a point now where we ban imaginary drugs and make life difficult for medical researchers without actually hindering the manufacturers of ‘legal highs’ – all they need to do is change a single atom in the molecule and the substance is unknown again. The legislation does not work as intended for anyone.

The questions section was the longest I had ever witnessed in a PubSci event. Even so, I came away from this talk with more questions:

  • How can we get accurate data on the harmful effects of narcotics in isolation? In the real world we don’t get someone admitted with just one thing in their system and to do so as a controlled experiment would be completely unethical.
  • Can we justify banning anything when alcohol abuse is filling our A&E wards on a regular weekly basis? On the one hand it feels a little bit like removing the brakes because road accidents are inevitable; On the other hand, I know of at least one case where a person refused medical attention for a copiously bleeding injury because he didn’t want to be ‘outed’ with substances in his system.
  • Does more money need to be spent on neurological research to remove the faulty parts of our brain that choose the reward response regardless of the cost to ourselves and others? I ask this as an unrepentant caffeine addict who is strongly opposed to drugs and tobacco. I fear the law may need to be made by more logical brains than we can offer it.
  • Who do I talk to about criminalising George Clooney’s eyes?

I don’t know who can answer these questions. Maybe you can help.

The PubSci organisers would like to thank Palaeosam for writing this review – check out his blog for other reviews and interesting stuff!

October PubSci: Designer Drugs 101

On Tuesday 23rd October we will have Dr James Moffatt discussing the pharmacology of recreational drugs and the chemistry behind what has made successful or unsuccessful drugs in recent history.

4-MMC 3D Molecule

We’ll look at the recent designer drug business model and consider the process of designing the type of drug we could synthesise and market, what the competition have to offer, and how it works within the law.

Finally, we’ll consider ways to prevent people from being exploited or harmed by such “designer drugs”.

If we ever came up with the perfect recreational drug, should we legalise it? Can you make a safe recreational drug, or are health risks unavoidable?

Join us for this fascinating insight into the science and legalities of designer drugs in the usual place at the usual time – Brixton Ritzy Upstairs Bar from 18:45ish for food, drink and a chat, for an 19:45ish start.

As usual the event is free!

*NEW DATE* July PubSci: Terrible Table Manners

Dave Hone will now be talking on the 24th July – apologies for any inconvenience caused.

PubSci update for June

This summer is shaping up to be governed by chaos and confusion. Between plans to add some new floor Upstairs at the Ritzy, European Cup football clashing with our PubSci date in June and the lumbering approach of a soulless reincarnated corporate monster originally spawned on the slopes of Mount Olympus that seems hell-bent on destroying London, the PubSci organisers have reached meltdown. As a result, the June PubSci has been put on hold.

But never fear! There are plenty of other interesting things to do that involve science and beer during June – check out the Londonist’s Week in Geek for starters. In case you want your monthly dose of rambling waffle from PubSci’s regular compère Paolo you can catch him talking about mermaids for the London Fortean Society on Thursday 31st May or you can attend the awesome science/theatre fusion event at the Enlightenment Cafe at some point over the Jubilee weekend.

Also, remember that there is the Hackney Skeptics in the Pub on June 25th with the next generation’s most promising skeptical mind and Randi Award winning grass-roots activist, Rhys Morgan.

We will hopefully be back Upstairs at the Ritzy in July (depending on the floor) with more science, beer and discussion. Enjoy the weather!